Microsatellite and chromosomal stable colorectal cancers demonstrate poor immunogenicity and early disease recurrence.

@article{Banerjea2009MicrosatelliteAC,
  title={Microsatellite and chromosomal stable colorectal cancers demonstrate poor immunogenicity and early disease recurrence.},
  author={Ayan Banerjea and Rebecca Eve Hands and Michael P Powar and Stephen Bustin and Sina Dorudi},
  journal={Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland},
  year={2009},
  volume={11 6},
  pages={601-8}
}
OBJECTIVE Colorectal cancers may demonstrate chromosomal instability (CSI) or microsatellite instability (MSI-H). A third group of microsatellite and chromosome stable (MACS) colorectal cancer has been described more recently. Patients with MSI-H colorectal cancers demonstrate improved outcome and a pronounced inflammatory infiltrate. Enhanced host immune response and increased immunogenicity might explain these observations. This study aims to further characterize colorectal cancer… CONTINUE READING