Microsatellite analysis of childhood brain tumors.

  title={Microsatellite analysis of childhood brain tumors.},
  author={Hendrik Bl{\"a}ker and B. K. Ahmed Rasheed and Roger E McLendon and Henry S. Friedman and Surinder K Batra and Herbert E. Fuchs and Sandra H. Bigner},
  journal={Genes, chromosomes & cancer},
  volume={15 1},
Loss of heterozygosity at specific chromosomal locations has been taken as evidence of a tumor suppressor gene located in that area. We performed a genomic allelotyping study on 46 childhood brain tumors of different histopathological types in order to identify and confirm common areas of deletion in different tumor types. Two hundred microsatellite DNA probes equally distributed over the 22 autosomes were applied, covering the genome in steps of approximately 25 cM. Our results confirm… CONTINUE READING
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