Microsatellite alterations in serum DNA of head and neck cancer patients

  title={Microsatellite alterations in serum DNA of head and neck cancer patients},
  author={Homaira Nawroz and Wayne Koch and Philippe Anker and Maurice Stroun and David Sidransky},
  journal={Nature Medicine},
Microsatellite DNA alterations are an integral part of neoplastic progression and are valuable as clonal markers for the detection of human cancers1–3. Moreover, recent evidence suggests that senescent tumor cells may release DNA into the circulation, which is subsequently carried by and therefore enriched in the serum and plasma4,5. We tested 21 patients with primary head and neck squamous cell carcinoma (HNSCC) by polymerase chain reaction (PCR)–based microsatellite analysis of DNA from… CONTINUE READING
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