Microsatellite alterations in adenoma and differentiated adenocarcinoma of the stomach.

@article{Tamura1995MicrosatelliteAI,
  title={Microsatellite alterations in adenoma and differentiated adenocarcinoma of the stomach.},
  author={Gen Tamura and Ken Sakata and Chihaya Maesawa and Yasushi Suzuki and Masanori Terashima and Kiichi Satoh and Saburo Sekiyama and Ayako Suzuki and Yoshiki Eda and Ryoichi Satodate},
  journal={Cancer research},
  year={1995},
  volume={55 9},
  pages={1933-6}
}
In order to elucidate the significance of the adenoma-carcinoma sequence in gastric carcinogenesis from a genetic point of view, we examined microsatellite alterations (replication error and loss of heterozygosity) on chromosomes 2p (D2S123), 3p (D3S1317), 5q (D5S409), 9p (IFNA), and 13q (D13S153) as well as p53 gene mutations in 13 adenomas and 23 differentiated adenocarcinomas including 8 early carcinomas of the stomach. Replication error was detected in only one of the adenomas (8%, 1/13) at… CONTINUE READING
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