Microsatellite allele 5 of MHC class I chain-related gene a increases the risk for insulin-dependent diabetes mellitus in latvians.

@article{ShtauvereBrameus2002MicrosatelliteA5,
  title={Microsatellite allele 5 of MHC class I chain-related gene a increases the risk for insulin-dependent diabetes mellitus in latvians.},
  author={A Shtauvere-Brameus and Mehran Ghaderi and Ingrida Rumba and Carani Balaraman Sanjeevi},
  journal={Annals of the New York Academy of Sciences},
  year={2002},
  volume={958},
  pages={349-52}
}
Insulin-dependent diabetes mellitus (IDDM) is one of the most common chronic diseases. It is an autoimmune, polygenic disease, associated with several genes on different chromosomes. The most important gene is human leukocyte antigen (HLA), also known as major histocompatibility complex (MHC), which is located on chromosome 6p21.3. HLA-DQ8/DR4 and DQ2/DR3 are positively associated with IDDM and DQ6 is negatively associated with IDDM in most Caucasian populations. The MICA gene is located in the… CONTINUE READING