Microsatellite Stable Colorectal Cancers Stratified by the BRAF V600E Mutation Show Distinct Patterns of Chromosomal Instability

@inproceedings{Bond2014MicrosatelliteSC,
  title={Microsatellite Stable Colorectal Cancers Stratified by the BRAF V600E Mutation Show Distinct Patterns of Chromosomal Instability},
  author={Catherine E Bond and D. J. Nancarrow and Leesa F Wockner and Leanne M. Wallace and Grant W. Montgomery and BarbaraA. Leggett and Vicki L. J. Whitehall},
  booktitle={PloS one},
  year={2014}
}
The BRAF (V600E) mutation in colorectal cancers that are microsatellite stable (MSS) confers a poor patient prognosis, whereas BRAF mutant microsatellite-unstable (MSI) colorectal cancers have an excellent prognosis. BRAF wild type cancers are typically MSS and display chromosomal instability (CIN). CIN has not been extensively studied on a genome-wide basis in relation to BRAF mutational status in colorectal cancer. BRAF mutant/MSS (BRAFmut/MSS) cancers (n = 33) and BRAF mutant/MSI (BRAFmut… CONTINUE READING
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