Microsatellite Instability in Double Primary Cancers of the Colorectum and Stomach

  title={Microsatellite Instability in Double Primary Cancers of the Colorectum and Stomach},
  author={Hee Sung Kim and Nam Bok Cho and Jae Hyung Yoo and K H Shin and J L Park and Yong Il Kim and Woo Ho Kim},
  journal={Modern Pathology},
Little is known about genetic alterations of patients who present multiple primary cancers. We hypothesized that microsatellite instability (MSI) is one of the underlying genetic factors in the development of double primary cancers in colorectal cancer patients. We examined for MSI in 41 colorectal cancer patients who presented with extra-colonic primary cancers consisted of 17 gastric and 24 non-gastric cancers. Coincident MSI+ in tumors of two organs were observed in 3 (17.7%) of 17 patients… CONTINUE READING


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Clinicopathologic characteristics of replication error-positive gastric carcinoma.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc • 1999
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