Microsatellite Instability, EMAST, and Morphology Associations with T Cell Infiltration in Colorectal Neoplasia

@article{Lee2011MicrosatelliteIE,
  title={Microsatellite Instability, EMAST, and Morphology Associations with T Cell Infiltration in Colorectal Neoplasia},
  author={Sun-Young Lee and Katsuya Miyai and Hye Seung Han and Dae Yong Hwang and Moo Kyung Seong and Heekyung Chung and Barbara H. Jung and Bikash Devaraj and Kathleen L. McGuire and John M. Carethers},
  journal={Digestive Diseases and Sciences},
  year={2011},
  volume={57},
  pages={72-78}
}
Colorectal tumors are often observed with tumor infiltrating lymphocytes, presumably as a host-immune response, and patterns may segregate by types of genomic instability. Microsatellite unstable (MSI) colorectal cancers contain a pronounced lymphocyte reaction that can pathologically identify these tumors. Colorectal tumors with elevated microsatellite alterations at selected tetranucleotide repeats (EMAST) have not been examined for lymphocyte patterns. We evaluated a 108-person cohort with… CONTINUE READING