Microprojection arrays to immunise at mucosal surfaces.

@article{McNeilly2014MicroprojectionAT,
  title={Microprojection arrays to immunise at mucosal surfaces.},
  author={Celia L. McNeilly and Michael Lawrence Crichton and Clare A. Primiero and Ian H Frazer and Michael S. Roberts and Mark A. F. Kendall},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2014},
  volume={196},
  pages={252-60}
}
The buccal mucosa (inner cheek) is an attractive site for delivery of immunotherapeutics, due to its ease of access and rich antigen presenting cell (APC) distribution. However, to date, most delivery methods to the buccal mucosa have only been topical-with the challenges of: 1) an environment where significant biomolecule degradation may occur; 2) inability to reach the APCs that are located deep in the epithelium and lamina propria; and 3) salivary flow and mucous secretion that may result in… CONTINUE READING
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