Microphysiological Systems to Assess Nonclinical Toxicity.

Abstract

The liver and the kidney are key toxicity target organs during drug development campaigns, as they typically carry the burden of drug transport and metabolism. Primary hepatocytes and proximal tubule epithelial cells grown in traditional in vitro 2-D culture systems do not maintain transporter and metabolic functions, thus limiting their utility for… (More)
DOI: 10.1002/cptx.27

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