Microphthalmia due to p53-mediated apoptosis of anterior lens epithelial cells in mice lacking the CREB-2 transcription factor.

@article{Hettmann2000MicrophthalmiaDT,
  title={Microphthalmia due to p53-mediated apoptosis of anterior lens epithelial cells in mice lacking the CREB-2 transcription factor.},
  author={T. Hettmann and K. Barton and J. Leiden},
  journal={Developmental biology},
  year={2000},
  volume={222 1},
  pages={
          110-23
        }
}
  • T. Hettmann, K. Barton, J. Leiden
  • Published 2000
  • Biology, Medicine
  • Developmental biology
  • CREB-2 (also called ATF4, TAXREB67, or C/ATF) is an evolutionarily conserved member of the CREB/ATF family of basic-leucine zipper transcription factors. CREB-2 is expressed ubiquitously in the adult mouse and can function as both a transcriptional activator and a repressor. However, little was understood about the normal function of CREB-2 in mammalian development or organ physiology. In this report we have used gene targeting to produce CREB-2-deficient (CREB-2-/-) mice. Adult CREB-2-/- mice… CONTINUE READING
    136 Citations
    Reduction of Spermatogenesis but Not Fertility in Creb3l4-Deficient Mice
    • 48
    • PDF
    Stabilization of ATF4 protein is required for the regulation of epithelial-mesenchymal transition of the avian neural crest.
    • 26
    • PDF
    Peroxidasin is essential for eye development in the mouse
    • 35
    • PDF
    PERK eIF2 alpha kinase is required to regulate the viability of the exocrine pancreas in mice
    • 66
    • PDF
    Over-expression of atf4 in Xenopus embryos interferes with neurogenesis and eye formation.
    • 1
    • PDF
    Lens ER-stress response during cataract development in Mip-mutant mice.
    • 24

    References

    SHOWING 1-10 OF 42 REFERENCES
    Regulation of Lens Fiber Cell Differentiation by Transcription Factor c-Maf*
    • 223
    • PDF
    Requirement for the c-Maf transcription factor in crystallin gene regulation and lens development.
    • 220
    • PDF
    Lens-specific expression of PDGF-A alters lens growth and development.
    • 107
    An Essential Role for Nuclear Factor κB in Promoting Double Positive Thymocyte Apoptosis
    • 226
    • PDF