Micropatterned three-dimensional hydrogel system to study human endothelial-mesenchymal stem cell interactions.

@article{Trkov2010MicropatternedTH,
  title={Micropatterned three-dimensional hydrogel system to study human endothelial-mesenchymal stem cell interactions.},
  author={Sasa Trkov and George Eng and Rosa Di Liddo and Pier Paolo Parnigotto and Gordana Vunjak-Novakovic},
  journal={Journal of tissue engineering and regenerative medicine},
  year={2010},
  volume={4 3},
  pages={205-15}
}
The creation of vascularized engineered tissues of clinically relevant size is a major challenge of tissue engineering. While it is known that endothelial and mural vascular cells are integral to the formation of stable blood vessels, the specific cell types and optimal conditions for engineered vascular networks are poorly understood. To this end, we investigated the vasculogenic potential of human mesenchymal stem cell (MSC) populations derived from three different sources: (a) bone marrow… CONTINUE READING