Microparticles initiate decompression-induced neutrophil activation and subsequent vascular injuries.

@article{Thom2011MicroparticlesID,
  title={Microparticles initiate decompression-induced neutrophil activation and subsequent vascular injuries.},
  author={Stephen R. Thom and Ming Yang and Veena M. Bhopale and Shaohui Huang and Tatyana N. Milovanova},
  journal={Journal of applied physiology},
  year={2011},
  volume={110 2},
  pages={340-51}
}
Progressive elevations in circulating annexin V-coated microparticles (MPs) derived from leukocytes, erythrocytes, platelets, and endothelial cells are found in mice subjected to increasing decompression stresses. Individual MPs exhibit surface markers from multiple cells. MPs expressing platelet surface markers, in particular, interact with circulating neutrophils, causing them to degranulate and leading to further MP production. MPs can be lysed by incubation with polyethylene glycol (PEG… CONTINUE READING