Microparticles in sickle cell anaemia: promise and pitfalls.

  title={Microparticles in sickle cell anaemia: promise and pitfalls.},
  author={Robert P. Hebbel and Nigel S Key},
  journal={British journal of haematology},
  volume={174 1},
Blood from patients with sickle cell disease contains microparticles (MP) derived from multiple cell sources, including red cells, platelets, monocytes and endothelial cells. MPs are of great interest because of their disease associations, their status as promising biomarkers, and the intercellular communications they mediate. To illustrate the likelihood of their relevance in sickle cell disease, we discuss the nature of MP, their profiling in sickle disease, some caveats relevant to their… CONTINUE READING