Microparticles as biomarkers in autoimmunity: from dust bin to center stage

@inproceedings{Pisetsky2009MicroparticlesAB,
  title={Microparticles as biomarkers in autoimmunity: from dust bin to center stage},
  author={David S. Pisetsky},
  booktitle={Arthritis research & therapy},
  year={2009}
}
Microparticles are small membrane-bound vesicles released from activated and dying cells. As shown in a study of primary Sjogren's syndrome, systemic lupus erythematosus and rheumatoid arthritis, levels of microparticles in the blood, as measured by a solid-phase prothrombinase assay or flow cytometry, are increased with autoimmunity. Among patients with these conditions, however, particle numbers were inversely related to disease activity and levels of the enzyme secretory phospholipase A2… CONTINUE READING