Microparticles and immunomodulation in pregnancy and pre-eclampsia.

  title={Microparticles and immunomodulation in pregnancy and pre-eclampsia.},
  author={Christopher W. G. Redman and Ian I L Sargent},
  journal={Journal of reproductive immunology},
  volume={76 1-2},
Cellular microparticles are ubiquitously shed from cell membranes or secreted as endocytic vesicles called exosomes. Shed microparticles are >/=100nm in size and are generated during apoptosis or necrosis. In contrast, exosomes are smaller (<100nm), express more limited protein content and are released from late endosomes. Both membrane particles and exosomes can be detected in the circulation in non-pregnant and pregnant women. In the former, they are increased in conditions associated with… CONTINUE READING
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