Microparticles and cancer.

  title={Microparticles and cancer.},
  author={Chirag Amin and Nigel Mackman and Nigel S Key},
  journal={Pathophysiology of haemostasis and thrombosis},
  volume={36 3-4},
Cancer is a prothrombotic state, with an increased prevalence of arterial and venous thromboemboli. Microparticles (MPs) are sub-micron-sized vesicles derived from activated or apoptotic cancer cells and/or host cells that may causally contribute to these clinical events, although the strength of the evidence thus far is inconclusive. We review the state-of-the-art understanding of the origin of circulating MPs, their role as a potentially important procoagulant entity in cancer, and their… CONTINUE READING
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