Microparticles, thrombosis and cancer.

  title={Microparticles, thrombosis and cancer.},
  author={Anat Aharon and Benjamin Brenner},
  journal={Best practice & research. Clinical haematology},
  volume={22 1},
Microvesicles comprised of exosomes and microparticles are shed from both normal and malignant cells upon cell activation or apoptosis. Microvesicles promote clot formation, mediate pro-inflammatory processes, facilitate cell-to-cell interactions, transfer proteins and mRNA to cells, and induce cell signalling. Microparticles bearing tissue factor play a central role in coagulation initiation and thrombus formation. This chapter will review earlier studies which focus on the role of… CONTINUE READING