Microparticle shape effects on margination, near-wall dynamics and adhesion in a three-dimensional simulation of red blood cell suspension.

@article{Vahidkhah2015MicroparticleSE,
  title={Microparticle shape effects on margination, near-wall dynamics and adhesion in a three-dimensional simulation of red blood cell suspension.},
  author={Koohyar Vahidkhah and Prosenjit Bagchi},
  journal={Soft matter},
  year={2015},
  volume={11 11},
  pages={2097-109}
}
We present a 3D computational modeling study of the transport of micro-scale drug carriers modeled as microparticles of different shapes (spherical, oblate, and prolate) in whole blood represented as a suspension of deformable red blood cells. The objective is to quantify the effect of microparticle shapes on their margination, near-wall dynamics and adhesion. We observe that the near-wall accumulation is highest for oblate particles of moderate aspect ratio, followed by spherical particles… CONTINUE READING
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