Micronucleus and comet assay in the peripheral blood of juvenile rat: establishment of assay feasibility, time of sampling and the induction of DNA damage.

@article{Mughal2010MicronucleusAC,
  title={Micronucleus and comet assay in the peripheral blood of juvenile rat: establishment of assay feasibility, time of sampling and the induction of DNA damage.},
  author={Amjad Ali Mughal and A. V. Vikram and Poduri Ramarao and Gopabandhu B Jena},
  journal={Mutation research},
  year={2010},
  volume={700 1-2},
  pages={86-94}
}
Micronucleus (MN) and comet assay can successfully detect the genetic damage in two different cell population of peripheral blood i.e. erythrocytes and lymphocytes. The present study was aimed to investigate the kinetics of MN formation as well as to identify the time of maximum MN induction in the peripheral blood erythrocytes in juvenile rats and thereafter to examine its relationship with the observed DNA damage in the lymphocytes as determined by comet assay. The rat peripheral blood… CONTINUE READING

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