Micronuclei induced by sulfur dioxide inhalation in mouse bone-marrow cells in vivo.

@article{Meng2002MicronucleiIB,
  title={Micronuclei induced by sulfur dioxide inhalation in mouse bone-marrow cells in vivo.},
  author={Zi-qiang Meng and Bo Zhang and Aidong Ruan and Nan Sang and JianBiao Zhang},
  journal={Inhalation toxicology},
  year={2002},
  volume={14 3},
  pages={303-9}
}
Induction effects of sulfur dioxide (SO2) inhalation on micronuclei (MN) formation in the polychromatic erythrocytes (PCE) of mouse bone marrow were studied in vivo. It was shown that SO2 inhalation caused an increase of MN frequencies in the PCE cells in a dose-dependent manner. These results from male and female mice were very similar; no sex difference was observed. These results imply that SO2 is a clastogenic and genotoxic agent.