Micronuclei in mice treated with monocrotaline with and without phenobarbital pretreatment

@article{Higgins1995MicronucleiIM,
  title={Micronuclei in mice treated with monocrotaline with and without phenobarbital pretreatment},
  author={Michael J. Higgins and Gyula Ficsor and C. S. Aaron and Thomas W. Petry and Roger L. Yu and Stephen B. Friedman},
  journal={Environmental and Molecular Mutagenesis},
  year={1995},
  volume={26}
}
Monocrotaline is a very potent toxin, producing significant effects of pneumotoxicity, hepatotoxicity, and teratogenicity, as well as carcinogenicity. In addition, the compound has been clearly shown to be muta‐genic after metabolic activation. The goal of the experiments reported here was to confirm the reported clastogenesis induced by this agent in vivo and to evaluate the impact of modulation of metabolic activity by phenobarbital, a potent P‐450 inducer (both Phase I and Phase II enzymes… 
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