Micronuclei in mice treated with monocrotaline with and without phenobarbital pretreatment

  title={Micronuclei in mice treated with monocrotaline with and without phenobarbital pretreatment},
  author={Michael J. Higgins and Gyula Ficsor and C. S. Aaron and Thomas W. Petry and Roger L. Yu and Stephen B. Friedman},
  journal={Environmental and Molecular Mutagenesis},
Monocrotaline is a very potent toxin, producing significant effects of pneumotoxicity, hepatotoxicity, and teratogenicity, as well as carcinogenicity. In addition, the compound has been clearly shown to be muta‐genic after metabolic activation. The goal of the experiments reported here was to confirm the reported clastogenesis induced by this agent in vivo and to evaluate the impact of modulation of metabolic activity by phenobarbital, a potent P‐450 inducer (both Phase I and Phase II enzymes… 
Lack of protective action of cysteine against the fetotoxic effect of monocrotaline.
Clustering of hepatotoxins based on mechanism of toxicity using gene expression profiles.
The results suggest that microarray assays may prove to be a highly sensitive technique for safety screening of drug candidates and for the classification of environmental toxins.
CD45RB Is a Novel Molecular Therapeutic Target to Inhibit Aβ Peptide-Induced Microglial MAPK Activation
Background Microglial activation, characterized by p38 MAPK or p44/42 MAPK pathway signal transduction, occurs in Alzheimer's disease (AD). Our previous studies demonstrated CD45, a membrane-bound


Modulation of monocrotaline-induced hepatic genotoxicity in rats.
Data provide further support for the association between DNA damage and the adverse hepatic effects of MCT and the observed effects on DNA cross-link induction.
Dehydroretronecine-induced rhabdomyosarcomas in rats.
The data indicate that either monocrotaline or its metabolite dehydroretronecine are capable of causing neoplastic transformations in the tissues of experimental animals.
Immunotoxicity of the pyrrolizidine alkaloid monocrotaline following subchronic administration to C57Bl/6 mice.
  • J. Deyo, N. Kerkvliet
  • Biology, Medicine
    Fundamental and applied toxicology : official journal of the Society of Toxicology
  • 1990
Toxicology and carcinogenic action of pyrrolizidine alkaloids.
Summary The studies of the hepatoxic and hepatocarcinogenic pyrrolizidine alkaloids (PA) have shown that ( a ) The conventional testing for toxicity and its evaluation on the basis of death occurring
Characterization of hepatic DNA damage induced in rats by the pyrrolizidine alkaloid monocrotaline.
Hepatic DNA damage induced by the pyrrolizidine alkaloid monocrotaline was evaluated and the presence of small numbers of DNA single-strand breaks could have been masked by the overwhelming predominance of DNA cross-links.