Micronuclei formation induced by X-ray irradiation does not always result from DNA double-strand breaks.

@article{Okada2012MicronucleiFI,
  title={Micronuclei formation induced by X-ray irradiation does not always result from DNA double-strand breaks.},
  author={Takuya Okada and Genro Kashino and Hideki Nishiura and Keizo Tano and Masami Watanabe},
  journal={Journal of radiation research},
  year={2012},
  volume={53 1},
  pages={93-100}
}
X-ray induced formation of micronuclei is generally thought to result from DNA double-strand breaks (DSBs). However, DNA DSBs inhibit the cell cycle progression that is required for micronucleus formation. In order to reconcile this apparent discrepancy, we investigated whether DNA DSBs induced during the G1 phase could lead to micronucleus formation. We irradiated human embryonic (HE17) cells that had been treated with a radical scavenger, either DMSO or ascorbic acid (AsA), and determined the… CONTINUE READING
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