Micronuclei, hemoglobin adducts and respiratory tract irritation in mice after inhalation of toluene diisocyanate (TDI) and 4,4'-methylenediphenyl diisocyanate (MDI).

@article{Lindberg2011MicronucleiHA,
  title={Micronuclei, hemoglobin adducts and respiratory tract irritation in mice after inhalation of toluene diisocyanate (TDI) and 4,4'-methylenediphenyl diisocyanate (MDI).},
  author={Hanna K Lindberg and Anne M Korpi and Tiina Santonen and Kirsi S{\"a}kkinen and Merja J{\"a}rvel{\"a} and Jarkko Tornaeus and Niina Ahonen and Hilkka J{\"a}rventaus and A L Pasanen and Christina Rosenberg and Hannu Norppa},
  journal={Mutation research},
  year={2011},
  volume={723 1},
  pages={1-10}
}
Toluene diisocyanate (TDI) and 4,4'-methylenediphenyl diisocyanate (MDI), used in the production of polyurethane foam, are well known for their irritating and sensitizing properties. Contradictory results have been obtained on their genotoxicity. We investigated the genotoxicity and protein binding of inhaled TDI and MDI in mice by examining micronucleated polychromatic erythrocytes (PCEs) in bone marrow and peripheral blood and TDI- and MDI-derived adducts in hemoglobin. Male C57Bl/6J mice (8… CONTINUE READING