Micronization of anti-inflammatory drugs for pulmonary delivery by a controlled crystallization process.

@article{Rasenack2003MicronizationOA,
  title={Micronization of anti-inflammatory drugs for pulmonary delivery by a controlled crystallization process.},
  author={Norbert Rasenack and Hartwig Steckel and Bernd W. M{\"u}ller},
  journal={Journal of pharmaceutical sciences},
  year={2003},
  volume={92 1},
  pages={35-44}
}
Jet-milling as the common way for micronization of drugs shows several disadvantages. Drug powder properties are decisive for pulmonary use because, besides a small particle size, a good deagglomeration behavior is required. In this study, several anti-inflammatory drugs [beclomethasone-17,21-dipropionate (BDP), betamethasone-17-valerate (BV), triamcinolone acetonide, ECU-R2, budesonide, and prednisolone] were micronized by controlled crystallization without any milling processes. First the… CONTINUE READING

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