Micron-scale holes terminate the phage infection cycle.

@article{Dewey2010MicronscaleHT,
  title={Micron-scale holes terminate the phage infection cycle.},
  author={Jill Sayes Dewey and Christos G Savva and Rebecca L. White and Stanislav Vitha and Andreas Holzenburg and Ry Young},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 5},
  pages={
          2219-23
        }
}
Holins are small phage-encoded proteins that accumulate harmlessly in the cytoplasmic membrane during the infection cycle until suddenly, at an allele-specific time, triggering to form lethal lesions, or "holes." In the phages lambda and T4, the holes have been shown to be large enough to allow release of prefolded active endolysin from the cytoplasm, which results in destruction of the cell wall, followed by lysis within seconds. Here, the holes caused by S105, the lambda-holin, have been… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 34 CITATIONS

Building-in biosafety for synthetic biology.

VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Deciphering Lysis and its Regulation in Bacteriophage T4

VIEW 21 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

Holin triggering in real time.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2011
VIEW 4 EXCERPTS
CITES METHODS & BACKGROUND

Lysis of bacterial cells in the process of bacteriophage release – canonical and newly discovered mechanisms

Zakład Biochemii Drobnoustrojów, Instytut Biochemii, Puławy Państwowy Instytut Badawczy, Wydział Rolnictwa
  • 2015
VIEW 5 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

References

Publications referenced by this paper.
SHOWING 1-10 OF 47 REFERENCES

Holins kill without warning.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2001
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Holins: the protein clocks of bacteriophage infections.

  • Annual review of microbiology
  • 2000
VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL

Holzenburg A (2008) Electron crystallography of biomolecules: Mysterious membranes and missing cones

RC Ford
  • Trends Biochem Sci 33:38–43
  • 2008
VIEW 1 EXCERPT

The fi nal step inthephageinfectioncycle : The Rz and Rz 1 lysis proteins link the inner and outer membranes

SummerEJ BerryJ, YoungR StruckDK
  • Mol Microbiol
  • 2008