Micrometastatic disease and metastatic outgrowth: clinical issues and experimental approaches.

@article{McGowan2009MicrometastaticDA,
  title={Micrometastatic disease and metastatic outgrowth: clinical issues and experimental approaches.},
  author={Patricia M. McGowan and Jennifer M. Kirstein and Ann F. Chambers},
  journal={Future oncology},
  year={2009},
  volume={5 7},
  pages={1083-98}
}
Metastasis from the primary tumor to distant organs is the principal cause of mortality in patients with cancer. While prognostic factors can predict which patients are likely to have their cancer recur, these are not perfect predictors, and some patient's cancers recur even decades after apparently successful treatment. This phenomenon is referred to as dormancy. Data from experimental studies have revealed two categories of metastatic dormancy: cellular dormancy, with solitary cancer cells in… CONTINUE READING