Micromechanics of isolated sickle cell hemoglobin fibers: bending moduli and persistence lengths.

@article{Wang2002MicromechanicsOI,
  title={Micromechanics of isolated sickle cell hemoglobin fibers: bending moduli and persistence lengths.},
  author={Jiang Cheng Wang and Matthew S. Turner and G Agarwal and Suzanna Kwong and Robert Josephs and Frank A. Ferrone and Robin W. Briehl},
  journal={Journal of molecular biology},
  year={2002},
  volume={315 4},
  pages={601-12}
}
Pathogenesis in sickle cell disease depends on polymerization of deoxyhemoglobin S into rod-like fibers, forming gels that rigidify red cells and obstruct the systemic microvasculature. Fiber structure, polymerization kinetics and equilibria are well characterized and intimately related to pathogenesis. However, data on gel rheology, the immediate cause of obstruction, are limited, and models for structure and rheology are lacking. The basis of gel rheology, micromechanics of individual fibers… CONTINUE READING