Micromechanics of human mitotic chromosomes.

  title={Micromechanics of human mitotic chromosomes.},
  author={Mingxuan Sun and Ryo Kawamura and John Frederick Daniel Marko},
  journal={Physical biology},
  volume={8 1},
Eukaryote cells dramatically reorganize their long chromosomal DNAs to facilitate their physical segregation during mitosis. The internal organization of folded mitotic chromosomes remains a basic mystery of cell biology; its understanding would likely shed light on how chromosomes are separated from one another as well as into chromosome structure between cell divisions. We report biophysical experiments on single mitotic chromosomes from human cells, where we combine micromanipulation, nano… CONTINUE READING
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