Micromarrows--three-dimensional coculture of hematopoietic stem cells and mesenchymal stromal cells.

  title={Micromarrows--three-dimensional coculture of hematopoietic stem cells and mesenchymal stromal cells.},
  author={Matthew M. Cook and Kathryn Futrega and Michael J Osiecki and Mahboubeh Kabiri and Betul Kul and Alison M Rice and K. Atkinson and Gary Brooke and Michael Robert Doran},
  journal={Tissue engineering. Part C, Methods},
  volume={18 5},
Hematopoietic stem cell (HSC) transplant is a well established curative therapy for some hematological malignancies. However, achieving adequate supply of HSC from some donor tissues can limit both its application and ultimate efficacy. The theory that this limitation could be overcome by expanding the HSC population before transplantation has motivated numerous laboratories to develop ex vivo expansion processes. Pioneering work in this field utilized stromal cells as support cells in… CONTINUE READING
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