Micromanaging aerobic respiration and glycolysis in cancer cells

@inproceedings{Orang2019MicromanagingAR,
  title={Micromanaging aerobic respiration and glycolysis in cancer cells},
  author={Ayla Valinezhad Orang and Janni Petersen and Ross A. McKinnon and Michael Z Michael},
  booktitle={Molecular metabolism},
  year={2019}
}
BACKGROUND Cancer cells possess a common metabolic phenotype, rewiring their metabolic pathways from mitochondrial oxidative phosphorylation to aerobic glycolysis and anabolic circuits, to support the energetic and biosynthetic requirements of continuous proliferation and migration. While, over the past decade, molecular and cellular studies have clearly highlighted the association of oncogenes and tumor suppressors with cancer-associated glycolysis, more recent attention has focused on the… CONTINUE READING
BETA
2
Twitter Mentions

Similar Papers

References

Publications referenced by this paper.
SHOWING 1-10 OF 456 REFERENCES

Cancer metabolism and the Warburg effect: the role of HIF-1 and PI3K

  • Molecular Biology Reports
  • 2015
VIEW 10 EXCERPTS
HIGHLY INFLUENTIAL

The Warburg effect: evolving interpretations of an established concept.

  • Free radical biology & medicine
  • 2015
VIEW 16 EXCERPTS
HIGHLY INFLUENTIAL

The hypoxia-inducible miR-429 regulates hypoxia-inducible factor-1α expression in human endothelial cells through a negative feedback loop.

  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2015
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Cancer metabolism: key players in metabolic reprogramming.

  • Cancer science
  • 2013
VIEW 17 EXCERPTS
HIGHLY INFLUENTIAL

Physiological regulation of Akt activity and stability.

  • American journal of translational research
  • 2010
VIEW 11 EXCERPTS
HIGHLY INFLUENTIAL

mTOR and HIF-1alpha-mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2009
VIEW 18 EXCERPTS
HIGHLY INFLUENTIAL

A microRNA signature of hypoxia.

  • Molecular and cellular biology
  • 2007
VIEW 11 EXCERPTS
HIGHLY INFLUENTIAL