Micromagnetic selection of aptamers in microfluidic channels.

  title={Micromagnetic selection of aptamers in microfluidic channels.},
  author={Xinhui Lou and Jiangrong Qian and Yi Xiao and Lisan Viel and A E Gerdon and Eric T. Lagally and Paul J. Atzberger and Theodore M Tarasow and Alan J. Heeger and H Tom Soh},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={106 9},
Aptamers are nucleic acid molecules that have been selected in vitro to bind to their molecular targets with high affinity and specificity. Typically, the systematic evolution of ligands by exponential enrichment (SELEX) process is used for the isolation of specific, high-affinity aptamers. SELEX, however, is an iterative process requiring multiple rounds of selection and amplification that demand significant time and labor. Here, we describe an aptamer discovery system that is rapid, highly… CONTINUE READING