Microiontophoretic studies of the effects of cylic nucleotides on excitability of neurones in the rat cerebral cortex.

@article{Stone1977MicroiontophoreticSO,
  title={Microiontophoretic studies of the effects of cylic nucleotides on excitability of neurones in the rat cerebral cortex.},
  author={Trevor W Stone and David Alan Taylor},
  journal={The Journal of physiology},
  year={1977},
  volume={266 3},
  pages={523-43}
}
1. Responses of cerebral cortical neurones to the microiontophoretic application of acetylcholine, noradrenaline, cyclic adenosine 3',5'-monophosphate (cyclic AMP) and cyclic guanosine 3',5'-monophosphate (cyclic GMP) were examined.2. The application of acetylcholine and cyclic GMP to identified pyramidal tract neurones resulted in an increased frequency of firing in a large number of cells. Upon application of both substances to cells which could not be identified as pyramidal tract cells, a… CONTINUE READING