Microinjections of acetaldehyde or salsolinol into the posterior ventral tegmental area increase dopamine release in the nucleus accumbens shell.

@article{Deehan2013MicroinjectionsOA,
  title={Microinjections of acetaldehyde or salsolinol into the posterior ventral tegmental area increase dopamine release in the nucleus accumbens shell.},
  author={Gerald A Deehan and Eric A. Engleman and Zheng-Ming Ding and William J H Mcbride and Zachary A. Rodd},
  journal={Alcoholism, clinical and experimental research},
  year={2013},
  volume={37 5},
  pages={722-9}
}
BACKGROUND Published findings indicate that acetaldehyde (ACD; the first metabolite of ethanol [EtOH]) and salsolinol (SAL; formed through the nonenzymatic condensation of ACD and dopamine [DA]) can be formed following EtOH consumption. Both ACD and SAL exhibit reinforcing properties within the posterior ventral tegmental area (pVTA) and both exhibit an inverted "U-shaped" dose-response curve. The current study was undertaken to examine the dose-response effects of microinjections of ACD or SAL… CONTINUE READING

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