Microinjection of the oncogene form of the human H-ras (T-24) protein results in rapid proliferation of quiescent cells.

Abstract

Using an E. coli expression-vector system we have efficiently produced, purified, and characterized the full-length, nonfused, protooncogenic and oncogenic (T-24) forms of the human H-ras gene product. These purified ras proteins have been introduced by microinjection into a variety of somatic cells in an effort to examine their function. Within several… (More)

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