Microinjection of strong calcium buffers suppresses the peak of calcium release during depolarization in frog skeletal muscle fibers

@article{Csernoch1993MicroinjectionOS,
  title={Microinjection of strong calcium buffers suppresses the peak of calcium release during depolarization in frog skeletal muscle fibers},
  author={L{\'a}szl{\'o} Csernoch and Vincent Jacquemond and Martin F. Schneider},
  journal={The Journal of General Physiology},
  year={1993},
  volume={101},
  pages={297 - 333}
}
The effects of high intracellular concentrations of various calcium buffers on the myoplasmic calcium transient and on the rate of release of calcium (Rrel) from the sarcoplasmic reticulum (SR) were studied in voltage-clamped frog skeletal muscle fibers. The changes in intracellular calcium concentration (delta[Ca2+]) for 200-ms pulses to 0-20 mV were recorded before and after the injection of the calcium buffer and the underlying Rrel was calculated. If the buffer concentration after the… CONTINUE READING

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