Microinjection of muscimol into raphe pallidus suppresses tachycardia associated with air stress in conscious rats.

@article{Zaretsky2003MicroinjectionOM,
  title={Microinjection of muscimol into raphe pallidus suppresses tachycardia associated with air stress in conscious rats.},
  author={Dmitry V Zaretsky and Maria V. Zaretskaia and B. C. Samuels and Laura K Cluxton and Joseph A Dimicco},
  journal={The Journal of physiology},
  year={2003},
  volume={546 Pt 1},
  pages={243-50}
}
Sympathetically mediated tachycardia is a characteristic feature of the physiological response to emotional or psychological stress in mammals. Activation of neurons in the region of the dorsomedial hypothalamus appears to play a key role in the integration of this response. Tachycardia evoked by chemical stimulation of the dorsomedial hypothalamus can be suppressed by microinjection of the GABA(A) receptor agonist and neuronal inhibitor muscimol into the raphe pallidus (RP). Therefore, we… CONTINUE READING

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