Microinjection of glutamate into the pedunculopontine tegmentum induces REM sleep and wakefulness in the rat.

@article{Datta2001MicroinjectionOG,
  title={Microinjection of glutamate into the pedunculopontine tegmentum induces REM sleep and wakefulness in the rat.},
  author={Subimal Datta and Eric E Spoley and Elissa H Patterson},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2001},
  volume={280 3},
  pages={R752-9}
}
The aim of this study was to test the hypothesis that the cells in the brain stem pedunculopontine tegmentum (PPT) are critically involved in the normal regulation of wakefulness and rapid eye movement (REM) sleep. To test this hypothesis, one of four different doses of the excitatory amino acid L-glutamate (15, 30, 60, and 90 ng) or saline (control vehicle) was microinjected unilaterally into the PPT while the effects on wakefulness and sleep were quantified in freely moving chronically… CONTINUE READING

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