Microinjection of fos-specific antibodies blocks DNA synthesis in fibroblast cells.

@article{Riabowol1988MicroinjectionOF,
  title={Microinjection of fos-specific antibodies blocks DNA synthesis in fibroblast cells.},
  author={Karl T. Riabowol and Robert J. Vosatka and Edward B Ziff and Ned J. C. Lamb and James R. Feramisco},
  journal={Molecular and cellular biology},
  year={1988},
  volume={8 4},
  pages={1670-6}
}
Transcription of the protooncogene c-fos is increased greater than 10-fold within minutes of treatment of fibroblasts with serum or purified growth factors. Recent experiments with mouse 3T3 cell lines containing inducible fos antisense RNA constructs have shown that induced fos antisense RNA transcripts cause either a marked inhibition of growth in continuously proliferating cells or, conversely, a minimal effect except during the transition from a quiescent (G0) state into the cell cycle… CONTINUE READING