Microinjection of cathepsin d induces caspase-dependent apoptosis in fibroblasts.

@article{Roberg2002MicroinjectionOC,
  title={Microinjection of cathepsin d induces caspase-dependent apoptosis in fibroblasts.},
  author={Karin Roberg and Katarina M K{\aa}gedal and Karin M Ollinger},
  journal={The American journal of pathology},
  year={2002},
  volume={161 1},
  pages={89-96}
}
Recent reports have indicated that enzymes such as cathepsins D and B are translocated from lysosomal compartments to the cytosol early during apoptosis. We have previously noted that a translocation of cathepsins D and B occur before cytochrome c release and caspase activation in cardiomyocytes and human fibroblasts during oxidative stress-induced apoptosis. In the present report, we use a microinjection technique to investigate if cytosolic location of the cathepsins D and B are important for… CONTINUE READING