Microhomology-mediated end joining is the principal mediator of double-strand break repair during mitochondrial DNA lesions

@inproceedings{Tadi2016MicrohomologymediatedEJ,
  title={Microhomology-mediated end joining is the principal mediator of double-strand break repair during mitochondrial DNA lesions},
  author={Satish Kumar Tadi and Robin Sebastian and Sumedha Dahal and Ravi K. Babu and Bibha Choudhary and Sathees C. Raghavan and Orna Cohen-Fix},
  booktitle={Molecular biology of the cell},
  year={2016}
}
Mitochondrial DNA (mtDNA) deletions are associated with various mitochondrial disorders. The deletions identified in humans are flanked by short, directly repeated mitochondrial DNA sequences; however, the mechanism of such DNA rearrangements has yet to be elucidated. In contrast to nuclear DNA (nDNA), mtDNA is more exposed to oxidative damage, which may result in double-strand breaks (DSBs). Although DSB repair in nDNA is well studied, repair mechanisms in mitochondria are not characterized… CONTINUE READING