Microhomology Directs Diverse DNA Break Repair Pathways and Chromosomal Translocations

@inproceedings{Villarreal2012MicrohomologyDD,
  title={Microhomology Directs Diverse DNA Break Repair Pathways and Chromosomal Translocations},
  author={Diana D. Villarreal and Kihoon Lee and Angela K. Deem and Eun Yong Shim and Anna Malkova and Sang Eun Lee},
  booktitle={PLoS genetics},
  year={2012}
}
Chromosomal structural change triggers carcinogenesis and the formation of other genetic diseases. The breakpoint junctions of these rearrangements often contain small overlapping sequences called "microhomology," yet the genetic pathway(s) responsible have yet to be defined. We report a simple genetic system to detect microhomology-mediated repair (MHMR) events after a DNA double-strand break (DSB) in budding yeast cells. MHMR using >15 bp operates as a single-strand annealing variant… CONTINUE READING
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