Microgrooved fibrillar collagen membranes as scaffolds for cell support and alignment.

@article{Vernon2005MicrogroovedFC,
  title={Microgrooved fibrillar collagen membranes as scaffolds for cell support and alignment.},
  author={Robert B. Vernon and Michel D. Gooden and Stephanie L. Lara and Thomas N Wight},
  journal={Biomaterials},
  year={2005},
  volume={26 16},
  pages={3131-40}
}
For several years, microgrooved substrates have been evaluated as a means to orient cells in engineered tissues. Recently, we fabricated thin (0.1-5.3 microm) planar and tubular collagen membranes (CMs) from air-dried hydrogels of native, fibrillar type I collagen (Vernon et al., Biomaterials 2004;26:1109-17). The CMs were strong, stable, and permeable and, hence, of potential use as scaffolds for tissue engineering. In the present study, planar CMs supported a robust attachment, spreading, and… CONTINUE READING