Microgravity and orthostatic intolerance: carotid hemodynamics and peripheral responses.

@article{Lacolley1993MicrogravityAO,
  title={Microgravity and orthostatic intolerance: carotid hemodynamics and peripheral responses.},
  author={P J Lacolley and Bruno M Pannier and J. L. Cuche and J S Hermida and St{\'e}phane Laurent and Pierre Maison-Blanche and J L Duchier and Bernard I L{\'e}vy and Michel E. Safar},
  journal={The American journal of physiology},
  year={1993},
  volume={264 2 Pt 2},
  pages={
          H588-94
        }
}
A ground-based model [24 h of bed rest (BR) with head-down tilt (HDT)] was used to investigate the cardiovascular deconditioning responsible for orthostatic intolerance, frequently observed after weightlessness flights. This experimental deconditioning is shown to be distinguished by an increase of mean blood pressure (P < 0.05), with increased total peripheral resistances (TPRs). Systolic tangential tension of the carotid arterial wall, cardiac output and frequency (spectral analysis), and… CONTINUE READING

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