Microgravity Reduces the Differentiation and Regenerative Potential of Embryonic Stem Cells.

@article{Blaber2015MicrogravityRT,
  title={Microgravity Reduces the Differentiation and Regenerative Potential of Embryonic Stem Cells.},
  author={Elizabeth A. Blaber and Hayley Finkelstein and Natalya Dvorochkin and Kevin Y. Sato and Rukhsana Yousuf and Brendan Paul Burns and Ruth K. Globus and Eduardo A C Almeida},
  journal={Stem cells and development},
  year={2015},
  volume={24 22},
  pages={
          2605-21
        }
}
Mechanical unloading in microgravity is thought to induce tissue degeneration by various mechanisms, including inhibition of regenerative stem cell differentiation. To address this hypothesis, we investigated the effects of microgravity on early lineage commitment of mouse embryonic stem cells (mESCs) using the embryoid body (EB) model of tissue differentiation. We found that exposure to microgravity for 15 days inhibits mESC differentiation and expression of terminal germ layer lineage markers… CONTINUE READING

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