Microglial senescence: does the brain's immune system have an expiration date?

@article{Streit2006MicroglialSD,
  title={Microglial senescence: does the brain's immune system have an expiration date?},
  author={Wolfgang J Streit},
  journal={Trends in Neurosciences},
  year={2006},
  volume={29},
  pages={506-510}
}
  • W. Streit
  • Published 1 September 2006
  • Medicine, Biology
  • Trends in Neurosciences
Microglia are seen as the sentries in the CNS who provide a first line of defense whenever there is injury or disease. Microglia and related perivascular macrophages perform various functions, ranging from immunological surveillance to neuroprotection. Recent work in the aged human brain has provided morphological evidence of structural deterioration of microglia, and work in rodents suggests that microglia are subject to replicative senescence (loss of mitotic ability after repeated rounds of… Expand
Life and Death of Microglia
TLDR
Cytorrhexis of microglia is infrequent in the normally aged human brain and non-detectable in aged rodents, but its occurrence increases dramatically during neurodegenerative conditions, including Alzheimer’s disease in humans and motoneuron disease in transgenic rats. Expand
Microglia in action: how aging and injury can change the brain’s guardians
TLDR
It is speculated that a deeper understanding of specific microglia identities will pave the way to develop more potent therapeutics to treat the diseases of aging brain. Expand
Microglia across the lifespan: from origin to function in brain development, plasticity and cognition
TLDR
This review highlights recent studies on microglial origin (from the embryonic yolk sac) and the factors regulating their differentiation and homeostasis upon brain invasion and the implications of the depletion or dysfunction of microglia for the authors' understanding of disease pathogenesis. Expand
Debris clearance by microglia: an essential link between degeneration and regeneration
TLDR
Understanding the mechanism and functional significance of microglial-mediated clearance of tissue debris following injury may open up exciting new therapeutic avenues. Expand
Microglia and Aging: The Role of the TREM2–DAP12 and CX3CL1-CX3CR1 Axes
TLDR
The role of the TREM2-DAP12 and CX3CL1-CX3CR1 axes in aged microglia and the involvement of these pathways in physiological CNS aging and in age-associated neurodegenerative diseases are reviewed. Expand
Microglial degeneration in the aging brain--bad news for neurons?
TLDR
The role microglial cells play in terms of amyloid clearance and degradation with the underlying idea that removal ofAmyloid constitutes a microglia neuroprotective function, which may become compromised during aging. Expand
General Physiology and Pathophysiology of Microglia During Neuroinflammation
TLDR
This review provides a comprehensive account of development and various physiological states of microglia and their role in healthy and disease brain. Expand
Physiology of Microglia.
TLDR
This work highlights studies that demonstrate the embryonic yolk sac origin of microglia and describes factors, including crosstalk with the periphery and external environment, that regulate their differentiation, homeostasis and function in the context of healthy CNS. Expand
Microglial Biology and Physiology
TLDR
Recent observations about microglia ontogeny combined with extensive gene expression profiling and emerged novel tools to study microglian biology allow us to characterize the variety of microglial phenotypes during development, homeostasis and disease. Expand
Microglial clearance function in health and disease
TLDR
Microglial cells are of hematopoietic origin, populate the CNS during early development and form the brain's innate immune cell type and have also pivotal roles during acute and chronic neurodegeneration. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 41 REFERENCES
Microglia as neuroprotective, immunocompetent cells of the CNS
TLDR
The fundamental interdependence of microglia and neurons is emphasized and the possibility of what could happen if microglial cells became dysfunctional as a result of aging, genetics, or epigenetics is looked at. Expand
Microglial phenotype: is the commitment reversible?
TLDR
Questions about what instructs microglia to acquire a particular phenotype, and how do these phenotypes differ, are addressed. Expand
Microglia and Alzheimer's disease pathogenesis
  • W. Streit
  • Psychology, Medicine
  • Journal of neuroscience research
  • 2004
TLDR
A comprehensive and critical look at the overall evidence supporting the neuroinflammation hypothesis and points out some weaknesses is taken, and evidence for an alternative theory, the microglial dysfunction hypothesis, is reviewed, which offers a different perspective on the identity of activated microglia and their role in AD pathogenesis. Expand
Control of glial immune function by neurons
TLDR
In brain tissue with intact neurons, the MHC class II inducibility of microglia and astrocytes by the proinflammatory cytokine IFN‐γ was reduced and control of MHC expression by neurons was dependent on their electrical activity. Expand
Microglia: a sensor for pathological events in the CNS
TLDR
An understanding of intercellular signalling pathways for microglia proliferation and activation could form a rational basis for targeted intervention on glial reactions to injuries in the CNS. Expand
Effects of axotomy on telomere length, telomerase activity, and protein in activated microglia
TLDR
Results show that microglia activated by injury are capable of maintaining telomere length via telomerase during periods of high proliferation in vivo, and conclude that molecular mechanisms pertaining to telomeres maintenance are active in the injured CNS. Expand
Effect of aging on the microglial response to peripheral nerve injury
TLDR
It is proposed that aging-related changes in morphology in conjunction with a less regulated proliferative response in the aged facial nucleus may be a reflection of microglial senescence. Expand
Physiology and Pathophysiology of Microglial Cell Function
TLDR
This first chapter is to provide a brief overview and synthesis of the subsequent chapters in this book and to elaborate on some favorite subjects, such as the role of microglia in the normal brain and their role in Alzheimer’s disease. Expand
Bone Marrow-Derived Microglia Play a Critical Role in Restricting Senile Plaque Formation in Alzheimer's Disease
TLDR
This work shows a massive infiltration of highly ramified and elongated microglia within the core of amyloid plaques in transgenic mouse models of Alzheimer's disease (AD), and shows that blood-derivedmicroglia and not their resident counterparts have the ability to eliminate amyloids deposits by a cell-specific phagocytic mechanism. Expand
Microglial cell population dynamics in the injured adult central nervous system
TLDR
The demonstration of an injury-enhanced recruitment of bone marrow-derived cells into the perforant path-denervated dentate gyrus, raises the possibility of using genetically manipulated cells as vectors for lesion-site-specific gene therapy even in minimally injured areas of the central nervous system. Expand
...
1
2
3
4
5
...