Microglial repopulation model reveals a robust homeostatic process for replacing CNS myeloid cells.

@article{Varvel2012MicroglialRM,
  title={Microglial repopulation model reveals a robust homeostatic process for replacing CNS myeloid cells.},
  author={Nicholas H. Varvel and Stefan A. Grathwohl and Frank Baumann and Christian Liebig and Andrea Bosch and Bianca Brawek and Dietmar Rudolf Thal and Israel F. Charo and Frank L Heppner and Adriano Aguzzi and O. V. Garaschuk and Richard M Ransohoff and Mathias Jucker},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2012},
  volume={109 44},
  pages={18150-5}
}
Under most physiological circumstances, monocytes are excluded from parenchymal CNS tissues. When widespread monocyte entry occurs, their numbers decrease shortly after engraftment in the presence of microglia. However, some disease processes lead to focal and selective loss, or dysfunction, of microglia, and microglial senescence typifies the aged brain. In this regard, the long-term engraftment of monocytes in the microglia-depleted brain remains unknown. Here, we report a model in which a… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS
87 Citations
49 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 87 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 49 references

Similar Papers

Loading similar papers…