Microglial release of nitric oxide by the synergistic action of beta-amyloid and IFN-gamma.

@article{Goodwin1995MicroglialRO,
  title={Microglial release of nitric oxide by the synergistic action of beta-amyloid and IFN-gamma.},
  author={Jerome L. Goodwin and Etsuro Uemura and Joan E. Cunnick},
  journal={Brain research},
  year={1995},
  volume={692 1-2},
  pages={207-14}
}
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized histopathologically by a loss of neurons and an accumulation of beta-amyloid plaques, neurofibrillary tangles, dystrophic neurites, and reactive glial cells. While most previous studies on the neurodegeneration of AD have focused on neuronal cells and direct beta-amyloid-mediated neurotoxicity, few have focused on the role of reactive glial cells in beta-amyloid-mediated neurotoxicity. In the present study nitric… CONTINUE READING
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