Microglial reactions after subcutaneous formalin injection into the rat hind paw.

@article{Fu1999MicroglialRA,
  title={Microglial reactions after subcutaneous formalin injection into the rat hind paw.},
  author={Kaiding Fu and Alan R. Light and Glenn K. Matsushima and William Maixner},
  journal={Brain research},
  year={1999},
  volume={825 1-2},
  pages={59-67}
}
Microglia in primary afferent projection territories are activated and proliferate after peripheral nerve injury. However, it is not known whether stimulation of peripheral nerves by noxious stimuli applied to their receptive fields activates microglial cells in the spinal cord. This study was designed to investigate the response of microglia in the lumbar spinal cord and in the brainstem to a tonic noxious stimulus. Thirty-two male Sprague-Dawley rats received subcutaneous injections of 5… CONTINUE READING