Microglial phenotype: is the commitment reversible?

  title={Microglial phenotype: is the commitment reversible?},
  author={Michal Schwartz and Oleg Butovsky and Wolfgang Br{\"u}ck and U. Hanisch},
  journal={Trends in Neurosciences},
Microglia, the standby cells for immune defense in the CNS, have a reputation for exacerbating the neural damage that occurs in neurodegenerative diseases. However, research over the past few years has established that microglia do not constitute a single, uniform cell population, but rather comprise a family of cells with diverse phenotypes--some that are beneficial and others that the CNS can barely tolerate and that are therefore destructive. This finding raised several questions. What… CONTINUE READING

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